Detalhe da pesquisa
1.
NTR 2.0: a rationally engineered prodrug-converting enzyme with substantially enhanced efficacy for targeted cell ablation.
Nat Methods
; 19(2): 205-215, 2022 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-35132245
2.
The Catalysis Mechanism of E. coli Nitroreductase A, a Candidate for Gene-Directed Prodrug Therapy: Potentiometric and Substrate Specificity Studies.
Int J Mol Sci
; 25(8)2024 Apr 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-38673999
3.
The Crystal Structure of Engineered Nitroreductase NTR 2.0 and Impact of F70A and F108Y Substitutions on Substrate Specificity.
Int J Mol Sci
; 24(7)2023 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37047605
4.
Hydrated Rubrolides from the New Zealand Tunicate Synoicum kuranui.
J Nat Prod
; 84(2): 544-547, 2021 02 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-33496582
5.
Directed evolution of the B. subtilis nitroreductase YfkO improves activation of the PET-capable probe SN33623 and CB1954 prodrug.
Biotechnol Lett
; 43(1): 203-211, 2021 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-32851465
6.
Lamellarin Sulfates from the Pacific Tunicate Didemnum ternerratum.
J Nat Prod
; 82(7): 2000-2008, 2019 07 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-31306000
7.
A cofactor consumption screen identifies promising NfsB family nitroreductases for dinitrotoluene remediation.
Biotechnol Lett
; 41(10): 1155-1162, 2019 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-31392514
8.
Evaluation of NfsA-like nitroreductases from Neisseria meningitidis and Bartonella henselae for enzyme-prodrug therapy, targeted cellular ablation, and dinitrotoluene bioremediation.
Biotechnol Lett
; 40(2): 359-367, 2018 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-29147875
9.
Correction to Lamellarin Sulfates from the Pacific Tunicate Didemnum ternerratum.
J Nat Prod
; 83(10): 3213, 2020 Oct 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-32964710
10.
Development of a compartmentalised self-replication protocol for selection of superior blunt-end DNA ligases.
Enzyme Microb Technol
; 163: 110153, 2023 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-36403327
11.
An inducible model of chronic hyperglycemia.
Dis Model Mech
; 16(8)2023 08 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37401381
12.
Preparation, analysis and toxicity characterisation of the redox metabolites of the azo food dye tartrazine.
Food Chem Toxicol
; 182: 114193, 2023 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-37980979
13.
A metagenomic library cloning strategy that promotes high-level expression of captured genes to enable efficient functional screening.
bioRxiv
; 2023 Mar 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-36993673
14.
A metagenomic library cloning strategy that promotes high-level expression of captured genes to enable efficient functional screening.
Cell Chem Biol
; 30(12): 1680-1691.e6, 2023 12 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-37898120
15.
Molecular regulation of retinal regeneration is context specific.
bioRxiv
; 2023 Nov 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-38045256
16.
Metathramycin, a new bioactive aureolic acid discovered by heterologous expression of a metagenome derived biosynthetic pathway.
RSC Chem Biol
; 2(2): 556-567, 2021 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34458799
17.
Engineering the Escherichia coli Nitroreductase NfsA to Create a Flexible Enzyme-Prodrug Activation System.
Front Pharmacol
; 12: 701456, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-34163368
18.
Large-scale phenotypic drug screen identifies neuroprotectants in zebrafish and mouse models of retinitis pigmentosa.
Elife
; 102021 06 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-34184634
19.
Engineering a Multifunctional Nitroreductase for Improved Activation of Prodrugs and PET Probes for Cancer Gene Therapy.
Cell Chem Biol
; 24(3): 391-403, 2017 Mar 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-28262557